Effect of Both Bisphenol - A and Liquorice on Some Sexual Hormones in Male Albino Rats and Illustration of the Effect of Stem Cell Enhancer on Their Actions
| Autor: | Dina Alsayed Zaki, Abeer Zakaria, Eman G.E. Helal, Mohamed A. Abdelaziz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Very low-density lipoprotein medicine.drug_class business.industry Prolactin Xenohormone 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology Xenoestrogen chemistry Estrogen Internal medicine medicine Endocrine system 030212 general & internal medicine Stem cell business Testosterone |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 77:5922-5929 |
| ISSN: | 2090-7125 |
| DOI: | 10.21608/ejhm.2019.65257 |
| Popis: | Background: Xenoestrogens are a type of xenohormone that imitates estrogen. They can be either synthetic or natural chemical compounds. Synthetic xenoestrogens include some widely used industrial compounds, such as PCBs, bisphenol A (BPA) and phthalates. "Dietary estrogen" is also called phytoestrogen, which is a plantderived xenoestrogen not generated within the endocrine system, but consumed by eating phytoestrogenic plants. Stem cell enhancer (SCE) (StemEnhance®) is a novel mobilizer of bone marrow adult stem cells that was shown to increase the number of circulating stem cells. Objectives: The aim of the current work was to clarify the effect of both BPA and liquorice together on some sexual hormones and illustration of the effect of stem cell enhancer on their actions. Materials and methods: Thirty male albino rats were used and were divided into three groups: Group I: control (untreated group), group II: rats treated with BPA and liquorice and group III: rats treated with BPA and anise oil in addition to stem cell enhancer. Blood samples were collected for different biochemical investigations. Results: There was a highly significant increase (p < 0.01) in the level of ALT and AST activities, urea, creatinine, FSH, prolactin, total cholesterol, triglycerides, LDL-C, VLDL, LDL/HDL and TC/HDL. While, there was highly significant decrease (p < 0.01) in HDL-C, total protein, albumin, globulin, testosterone and LH. These results turned back to the normal values after receiving the SCE as compared to normal group. Conclusion: It could be concluded that phytoestrogen and xenoeostrogen have undesirable effects and it is recommended to minimize the utilization of these compounds to protect people from its hazardous effects. |
| Databáze: | OpenAIRE |
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