Structure-property relationship for description of apoptosis (programmed cell death) induction by phenol derivatives

Autor:	S. M. Zhenodarova, I. G. Tsygankova
Rok vydání:	2008
Předmět:	Programmed cell death chemistry.chemical_compound Biochemistry Chemistry Apoptosis Structure property Phenol General Chemistry Leukemia L1210
Zdroj:	Russian Journal of General Chemistry. 78:1760-1766
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363208090181
Popis:	Structure-property relationship based on fragment descriptors of molecular structure was used to assess the ability of phenol derivatives to induce apoptosis in L1210 leukemia cells in mice. Simple models that provide quite accurate estimates for the apoptic activity of various phenol compounds were suggested. Such models allow one to clearly interpret the contributions of structural elements of phenol derivatives and to predict how their apoptic activity will vary with structural modification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e4829e90761b8c5fc933a2f9fba55336 https://doi.org/10.1134/s1070363208090181 Zobrazit plný text záznamu Plný text ve formátu PDF