Pharmacological potential of methanol extract of Anacardium occidentale stem bark on alloxan-induced diabetic rats
| Autor: | D. A. Omoboyowa, F. O. Afolabi, T. C. Aribigbola |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant biology Chemistry medicine.medical_treatment Anacardium Intraperitoneal injection 030209 endocrinology & metabolism Pharmacology biology.organism_classification medicine.disease General Biochemistry Genetics and Molecular Biology Glibenclamide 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Phytochemical Diabetes mellitus Alloxan medicine Saline medicine.drug |
| Zdroj: | Biomedical Research and Therapy. 5:2440-2454 |
| ISSN: | 2198-4093 |
| DOI: | 10.15419/bmrat.v5i7.456 |
| Popis: | Background: The anti-hyperglycemic potential of methanol stem bark extract of Anacardium occidentale (MSBEAO) was investigated using an alloxan-induced diabetic rat model. Alloxan administration induces the generation of free radicals which can affect antioxidant status resulting in the disruption of the β-cells of the pancreas. Therefore, this study examines the antioxidant potential of the plant extract and the ameliorating effect on the pancreas of alloxan-induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of 150 mg/kg body weight of alloxan monohydrate. MSBEAO, at a concentration of 100 or 200 mg/kg b.w. was orally administered to alloxan-induced diabetic rats and normal rats. The hypoglycemic effect, oral glucose tolerance test, and biochemical assay of alloxan-induced diabetic rats were assayed using standard procedures. Results: Preliminary phytochemical screening of the extract revealed the presence of alkaloids, tannins, saponins, terpenoids, carbohydrates, and phenols at moderate concentrations. The lethality dose (LD50) of the plant extract was found to be equal to or less than 5000 mg/kg b.w. The hypoglycemic effect of the extract on the non-diabetic rats revealed a significant (p |
| Databáze: | OpenAIRE |
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