Complex Karyotype with PH1Chromosome in Myelodysplasia: Cytogenetic and Molecular Studies

Autor:	Irma Slavutsky, Isabel Giere, Raquel Bengió, Susana Acevedo, Irene Larripa, Marina Gutiérrez
Rok vydání:	1992
Předmět:	Ineffective erythropoiesis Cancer Research Acute leukemia breakpoint cluster region Chromosome Myeloid leukemia Hematology Biology medicine.disease_cause Philadelphia chromosome medicine.disease Molecular biology Oncology hemic and lymphatic diseases Complex Karyotype medicine Southern blot
Zdroj:	Leukemia & Lymphoma. 6:401-406
ISSN:	1029-2403 1042-8194
Popis:	We report here a patient with Ph1-positive myelodysplasia with a complex karyotype. The patient presented with severe refractory anemia and ineffective erythropoiesis. In addition to t(9;22), chromosomes no. 1, 11, 12 and X also showed structural aberrations. Serial chromosome analyses revealed an increase of the Ph1-positive cell line along with the evolution of the disease (50% to 100%). Southern blot analysis showed a breakpoint cluster region (bcr) rearrangement as described for chronic myeloid leukemia (CML). The disease evolved into an acute leukemia after 4 years without any clinical evidences of CML.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e475112e23af4eddd97b86764d5fb53d https://doi.org/10.3109/10428199209053573 Zobrazit plný text záznamu