Phosphoinositides and phagocytosis
| Autor: | Harald Stenmark, David J. Gillooly, Anne Simonsen |
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| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Journal of Cell Biology. 155:15-18 |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.200109001 |
| Popis: | Phosphoinositide 3 kinases (PI3Ks)**Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P3) and phosphatidylinositol 3-phosphate (PI[3]P), accumulate transiently at different stages. Phagosomes containing Mycobacterium tuberculosis do not acquire the PI(3)P-binding protein EEA1, which is required for phagosome maturation. This suggests a possible mechanism of how this microorganism evades degradation in phagolysosomes. |
| Databáze: | OpenAIRE |
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