Characterization of 11 commercial pyrethroids on the functional attributes of rat brain synaptosomes
| Autor: | Richard K. Frisbie, J. Marshall Clark, Steven B. Symington |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Synaptosome
Chromatography organic chemicals Health Toxicology and Mutagenesis Tefluthrin Bifenthrin Glutamate receptor Neurotoxicity General Medicine Pharmacology medicine.disease Cypermethrin chemistry.chemical_compound Deltamethrin chemistry parasitic diseases medicine heterocyclic compounds Bioallethrin Agronomy and Crop Science |
| Zdroj: | Pesticide Biochemistry and Physiology. 92:61-69 |
| ISSN: | 0048-3575 |
| Popis: | The action of 11 commercial pyrethroids on Ca 2+ influx and glutamate release was assessed using high-throughput functional assays with rat brain synaptosomes to better understand the mechanistic nature of pyrethroid-induced neurotoxicity and aid in the reassessment of pyrethroids in vivo . Concentration-dependent response curves for each of the non-cyano and α-cyano containing pyrethroids were determined and the data used in a cluster analysis. The previously characterized α-cyano pyrethroids that induce the CS-syndrome (cypermethrin, deltamethrin, and esfenvalerate) increased Ca 2+ influx and glutamate release, and clustered with two other α-cyano pyrethroids (β-cyfluthrin and λ-cyhalothrin) that shared these same actions. Previously characterized T-syndrome pyrethroids (bioallethrin, cismethrin, and fenpropathrin) did not share these actions and clustered with two other non-cyano pyrethroids (tefluthrin and bifenthrin) that likewise did not elicit these actions. Our current findings indicate that pyrethroids that have an α-cyano group (with the exception of fenpropathrin) were more potent enhancers of Ca 2+ influx and glutamate release under depolarizing conditions than pyrethroids that did not possess this functional group. The collective data set does not support the hypothesis that pyrethroids, as a class, act in a similar fashion at presynaptic nerve terminals. |
| Databáze: | OpenAIRE |
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