Donor transmitted mutation of the ABCB11 gene and ensuing intrahepatic cholestasis of pregnancy in a liver transplant recipient
| Autor: | Catherine Williamson, Iona Coltart, Richard B. Thompson, Rosa Miquel, Tiong Yeng Lim, Michael A. Heneghan, Pierre Foskett, Sandra Strautnieks, Leonie Penna |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Transplantation
medicine.medical_specialty Pregnancy 030219 obstetrics & reproductive medicine Hepatology medicine.diagnostic_test business.industry medicine.medical_treatment Gallstones Liver transplantation medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Endocrinology Cholestasis Liver biopsy Internal medicine medicine 030211 gastroenterology & hepatology Surgery ABCB11 Liver function tests business Cholestasis of pregnancy |
| Zdroj: | Liver Transplantation. 23:1229-1232 |
| ISSN: | 1527-6473 1527-6465 |
| DOI: | 10.1002/lt.24776 |
| Popis: | In liver transplant (LT) recipients, the cause of graft dysfunction in pregnancy is often difficult to ascertain. Moreover, a liver biopsy in late pregnancy is often avoided as a consequence of patient and physician factors. Management of graft dysfunction can be difficult in this setting. We report a 30-year-old female LT recipient who developed acutely deranged liver biochemistry during the third trimester of her first pregnancy. At 29 weeks gestation, her liver function test (LFT) became abnormal; AST peaked at 978 IU/L (normal range 10-50), GGT 25 IU/L (normal range 1-55), bilirubin 1.5 mg/dL (normal range 0.3-1) and serum bile acids 52 µmol/L (normal range |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text