Evaluation of neuroprotective properties of Ademol with experimental traumatic brain injury conditions

Autor:	O. A. Khodakivsky, N. O. Semenenko, O. M. Semenenko, O. O. Yakovleva, S Semenenko
Rok vydání:	2019
Předmět:	Traumatic brain injury business.industry Experimental model Anesthesia Therapeutic effect medicine General Medicine medicine.disease business Neuroprotection Complex problems
Zdroj:	Reports of Vinnytsia National Medical University. 23:209-211
ISSN:	2522-9354 1817-7883
DOI:	10.31393/reports-vnmedical-2019-23(2)-04
Popis:	The choice of drugs in traumatic injuries of the head is one of the most complex problems in the complex treatment of such patients. The aim was to estimate the cerebroprotective action of Ademol on the indicator of lethality of rats against the background of an experimental traumatic brain injury (TBI). The experimental model of the TBI of severe severity was caused by the action of the flow of carbon dioxide under pressure that was created using a gas cylinder pneumatic gun. The therapeutic effect of Ademol on the model TBI was evaluated at doses of 1, 2 and 4 mg/kg intravenously. Pseudo-operative animals and control group received a 0.9% NaCl solution at a dose of 2 ml/kg. The results were processed using the statistical program StatPlus 2009. Used Fisher angular transformation when accounting for results in an alternative form. In the course of the experiment, it was found that in the control group at the end of the experiment, 8 days after the TBI model, death of 90% of the rats was recorded p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e456c712da2ea82099b1f92a216fce2c https://doi.org/10.31393/reports-vnmedical-2019-23(2)-04 Zobrazit plný text záznamu