A comparison of 99mTc-DTPA clearance and translocation of nano particles in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
| Autor: | Alejandro Sanchez-Crespo, Magnus Svartengren, Maria Diakopoulou, Martin Anderson, Mikaela Qvarfordt |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
COPD Lung business.industry Nanoparticle Chromosomal translocation respiratory system medicine.disease Gastroenterology respiratory tract diseases Idiopathic pulmonary fibrosis Nebulizer medicine.anatomical_structure Internal medicine medicine business Diffuse alveolar damage Half time |
| Zdroj: | Occupational and environmental health. |
| Popis: | There is a link between acute elevated air pollution levels and adverse health effects. One explanation could be translocation of particles deposited in the lungs into the blood stream. In the present study we studied particle translocation from lung to blood stream in persons with alveolar damage, both chronic obstructive pulmonary disease (COPD) and idiopathic lung fibrosis (IPF). We exposed 11 subjects with COPD and emphysema, as well as in 9 subjects with IPF, to radioactively labelled carbon nano particles (Technegas®). Both groups also inhaled an aerosol of 99mTc-DTPA using a SmartVent™ nebulizer system. Clearance of both nano particles and DTPA was calculated using planar scintigraphy. Nano particle clearance was measured for 10 days and DTPA clearance for 45 minutes. On average the initial activity was reduced by 50% at 51 min for COPD and 34 min for IPF. As for carbon nano particles, DTPA clearance was higher in both groups than for healthy subjects, but there was no correlation between DTPA clearance measured as half time, and nano particle clearance measured neither 2 h (r = 0.17), nor 10 days (r In conclusion, both in subjects with COPD and with IPF, alveolar damage (of different type) leads to impaired integrity of the alveolar membrane and hence increased leakage from the lung of both carbon nano particles and DTPA. However, there was no apparent correlation between the two methods, and consequently DTPA clearance has little value in predicting lung-blood translocation of inhaled nano particles in human lung. |
| Databáze: | OpenAIRE |
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