Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro

Autor:	Holger A Russ, Audrey V Parent, Jennifer J Ringler, Thomas G Hennings, Gopika G Nair, Mayya Shveygert, Tingxia Guo, Sapna Puri, Leena Haataja, Vincenzo Cirulli, Robert Blelloch, Greg L Szot, Peter Arvan, Matthias Hebrok
Rok vydání:	2015
Předmět:	medicine.medical_specialty General Immunology and Microbiology General Neuroscience Cellular differentiation Insulin medicine.medical_treatment Biology medicine.disease Embryonic stem cell General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Endocrinology Directed differentiation Cell culture Diabetes mellitus Internal medicine medicine Cancer research Progenitor cell Pancreas Molecular Biology
Zdroj:	The EMBO Journal. 34:1759-1772
ISSN:	1460-2075 0261-4189
DOI:	10.15252/embj.201591058
Popis:	Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e45334c58e9c6e76fab4e329b3e9659b https://doi.org/10.15252/embj.201591058 Zobrazit plný text záznamu Plný text