Propranolol antagonism of marihuana induced tachycardia
| Autor: | Robert Martz, D. J. Brown, Thomas P. Bright, Robert B. Forney, Glenn F. Kiplinger, Bruce E. Rodda |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Tachycardia
business.industry General Medicine Propranolol Pharmacology Placebo General Biochemistry Genetics and Molecular Biology Double blind Anesthesia Heart rate Medicine General Pharmacology Toxicology and Pharmaceutics medicine.symptom business Antagonism Completely randomized design medicine.drug |
| Zdroj: | Life Sciences. 11:999-1005 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(72)90179-8 |
| Popis: | The experiment was conducted on a double blind basis according to a completely randomized design. There were four groups consisting of six subjects each as follows: propranolol pretreatment plus marihuana; propranolol pretreatment plus placebo marihuana; placebo propranolol pretreatment plus marihuana; and placebo propranolol pretreatment plus placebo marihuana. Smoking of active marihuana resulted in a significant increase in heart rate. The prior administration of propranolol antagonized the marihuana induced tachycardia both in magnitude and duration. However, propranolol pretreatment neither decreased the number of responses on the Cornell Medical Index following the smoking of marihuana nor interfered with the subject's ability to distinguish active marihuana from placebo marihuana. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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