A New Route for the Preparation of 5-Hydroxyisophthalic Acid

Autor:	Mark Gelmont, Oded Arad, Jakob Oren
Rok vydání:	2002
Předmět:	Bromine Aqueous solution Organic Chemistry chemistry.chemical_element Oleum Catalysis law.invention Isophthalic acid chemistry.chemical_compound Hydrolysis chemistry law Yield (chemistry) Organic chemistry Physical and Theoretical Chemistry Crystallization
Zdroj:	Organic Process Research & Development. 7:121-121
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op0200930
Popis:	A new, simple and practical, two-stage process for the preparation of 5-hydroxyisophthalic acid (5-HIPA) from isophthalic acid is described. In the first stage, isophthalic acid is brominated by bromine in oleum, in the presence of an iodine catalyst, to give crude 5-bromoisophthalic acid (5-BIPA). In the second stage the crude 5-BIPA is hydrolyzed with aqueous NaOH, in the presence of a copper catalyst, to give crude 5-HIPA, with a purity of ca. 98%. Both stages of the process were optimized. A single crystallization of the crude 5-HIPA from water gives the product in a purity of more than 99%. The overall yield of pure 5-HIPA is 65−70%.
Databáze:	OpenAIRE
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