HYPERVOLEMIA IN MICE BEARING GRANULOSA CELL GROWTHS; TIME OF ONSET AND SOME ASSOCIATED PHYSIOLOGICAL AND CHEMICAL CHANGES1
Autor: | Harry Sobel, Jacob Furth |
---|---|
Rok vydání: | 1948 |
Předmět: | |
Zdroj: | Endocrinology. 42:436-447 |
ISSN: | 1945-7170 0013-7227 |
DOI: | 10.1210/endo-42-6-436 |
Popis: | It was noted recently that mice bearing subcutaneous growths of transplanted granulosa cells have enormously congested livers and adrenals (Furth and Boon, 1945) and an associated hypervolemia with 2 to 3 times normal values (Furth and Sobel, 1947). The hypervolemia is present in mice bearing transplanted granulosa cell tumors originally induced by x-rays (Furth and Sobel, 1946) or produced by intrasplenic grafts of ovarian fragments into gonadectomized mice (Furth and Sobel, 1947). It was suggested that this increase in blood volume was produced, directly or indirectly, by a hypothetical substance elaborated by the neoplastic granulosa cell. The physiological and chemical studies reported here were undertaken to learn more about the nature of this hypervolemia. materials and methods The origin of the transplantable granulosa cell tumors used in this experiment has already been described (Furth and Sobel, 1946; 1947). Strain V, an x-ray induced tumor, was in its 8th and 9th passage with one exception |
Databáze: | OpenAIRE |
Externí odkaz: |