Mitoimmunity-when mitochondria dictates macrophage function
| Autor: | Felipe Corrêa-da-Silva, Jessica Aparecida da Silva Pereira, Cristhiane Favero de Aguiar, Pedro M. Moraes-Vieira |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chemistry Inflammation Inflammasome Cell Biology General Medicine Mitochondrion Proinflammatory cytokine Cell biology Citric acid cycle 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine Macrophage Cytokine secretion medicine.symptom Beta oxidation 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cell Biology International. 42:651-655 |
| ISSN: | 1065-6995 |
| Popis: | In the past decade, several reports have appointed the importance of mitochondria in the immune response. Our understanding of mitochondria evolved from a simple supplier of energy into a platform necessary for immunorregulation. Proinflammatory responses are associated with enhanced glycolytic activity and breakdown of the TCA cycle. Mitochondrial reactive species of oxygen (mROS) are key regulators of classically activated macrophages, with substantial impact in the anti-microbicidal activity and pro-inflammatory cytokine secretion of macrophages. The inflammasome activation in macrophages is dependent on mROS production and mitochondrial regulation and mitochondrial dynamics and functionality direct impact inflammatory responses. Alternative activated macrophage metabolism relies on fatty acid oxidation, and the mechanism responsible for this phenotype is not fully elucidated. Thus, cellular metabolism and mitochondria function is a key immunoregulatory feature of macrophage biology. In this review, we will provide insights into recently reported evidences of mitochondria-related metabolic nodes, which are important for macrophage physiology. |
| Databáze: | OpenAIRE |
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