Chemoselective Oxidation of p-Methoxybenzyl Ethers by an Electronically Tuned Nitroxyl Radical Catalyst

Autor:	Shohei Hamada, Elghareeb E. Elboray, Takumi Furuta, Koichi Sugimoto, Takeo Kawabata
Rok vydání:	2020
Předmět:	chemistry.chemical_compound 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Chemistry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Organic Chemistry Nitroxyl Physical and Theoretical Chemistry Biochemistry Medicinal chemistry Catalysis
Zdroj:	Organic Letters. 22:5486-5490
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.0c01839
Popis:	The oxidation of p-methoxy benzyl (PMB) ethers was achieved using nitroxyl radical catalyst 1, which contains electron-withdrawing ester groups adjacent to the nitroxyl group. The oxidative deprotection of the PMB moieties on the hydroxy groups was observed upon treatment of 1 with 1 equiv of the co-oxidant phenyl iodonium bis(trifluoroacetate) (PIFA). The corresponding carbonyl compounds were obtained by treating the PMB-protected alcohols with 1 and an excess of PIFA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e43d1db7d6ffa85679f56ba17c876e0d https://doi.org/10.1021/acs.orglett.0c01839 Zobrazit plný text záznamu