Synthesis, stability, and radiolytic decomposition of carbon-14 labeled MK0677
| Autor: | Ravi P. Nargund, David G. Melillo, Michael A. Wallace, Allen N. Jones, Herb Jenkins, Dennis C. Dean |
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| Rok vydání: | 1996 |
| Předmět: |
chemistry.chemical_classification
Ethanol Organic Chemistry Biochemistry Peroxide Decomposition Chemical synthesis Analytical Chemistry chemistry.chemical_compound chemistry Drug Discovery Radiolysis Benzyl group Organic chemistry Radiology Nuclear Medicine and imaging Carbon-14 Compounds of carbon Spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 38:561-565 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/(sici)1099-1344(199606)38:6<561::aid-jlcr872>3.0.co;2-s |
| Popis: | MK0677 is an orally active growth hormone secretagogue. The crystallized carbon-14 labeled material was found to undergo radiolytic decomposition via a peroxide intermediate which resulted in loss of the benzyl group. The rate was diminished when the tracer was crystallized from nitrogen-degassed solvents. Storage stability was best in aqueous ethanol. |
| Databáze: | OpenAIRE |
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