| Popis: |
The effects of N-benzyl-D-glucaminedithiocarbamate (BGD), N-benzyl-D-galactamine dithiocarbamate (BGalD), N-p-methylbenzyl-D-glucamine dithiocarbamate (MeBGD), penicillamine (D-PEN), triethylenetetramine·2HCl (Trien), on the excretion and the distribution of copper were compared in male LEC rats (5 weeks). Rats were injected intraperitoneally with chelating agents (2 mmol/kg) every other day for 10 d. The hepatic copper content after treatment with BGD and MeBGD decreased more than that with D-PEN and Trien. Those treatment with dithiocarbamates did not redistribute copper to kidneys and brain. BGD, BGalD and MeBGD all significantly enhanced the biliary excretion of copper, zinc and iron. |
