Synthesis of a mitomycin C–lexitropsin hybrid

Autor:	Elise Champeil, Anne-Marie Sapse
Rok vydání:	2014
Předmět:	Chemistry medicine.drug_class Stereochemistry General Chemical Engineering Lexitropsin Mitomycin C Carboxamide General Chemistry Coupling reaction Red shift chemistry.chemical_compound medicine Conjugate Pyrrole
Zdroj:	Comptes Rendus Chimie. 17:1190-1196
ISSN:	1631-0748
DOI:	10.1016/j.crci.2014.03.004
Popis:	We have constructed hybrid drugs where mitomycin C is linked to the N -methylpyrrole carboxamide framework present in lexitropsins. The coupling reactions leading to these products are efficient and the yields are very high. An interesting spectroscopic feature of these hybrids is the red shift observed in the UV–vis spectrum. Although DFT calculations indicate the possible existence of complexes formed during the coupling reactions, these complexes were not detected. The only species produced and isolated were the mitomycin C-mono- and bis- N -methyl pyrrole conjugates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e42b7ffb95e4ea198b73c306f505767e https://doi.org/10.1016/j.crci.2014.03.004 Zobrazit plný text záznamu