941 PREVALENCE OF VITAMIN K DEFICIENCY IN NEWBORN INFANTS: INFLUENCE OF PERINATAL RISK FACTORS
| Autor: | Marilyn J. Manco-Johnson, Linda J. Jacobson, W E Hathaway, Amy P Shapiro, Peter Hulac, Peter A. Lane |
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| Rok vydání: | 1985 |
| Předmět: | |
| Zdroj: | Pediatric Research. 19:267A-267A |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198504000-00971 |
| Popis: | Measurement of noncarboxylated prothrombin (PIVKA-II assay) was used to study 559 infants for vitamin K (vit K) deficiency. This test, performed by immunoelectrophoresis of plasma before and after BaCO3 precipitation, is sensitive to 0.03 u/ml PIVKA-II, has an intra- and inter-test coefficient of variation of 3-5%, and is negative in liver disease. Catagories of infants studied and results are as follows. As part of an ongoing study of 1,000 cord bloods, 534 cords were assayed and 2.6% were PIVKA-II positive (0.03-0.15 u/ml). The PT of the PIVKA-II positive samples ranged from 11.5-23 seconds and correlated inversely with prothrombin activities of 10-55%. SGA infants were at increased risk for K deficiency (14%); however, other groups were not (preterm, post-term, infants with fetal distress, and infants of mothers with hypertension or third trimester infection), Interestingly, of 16 infants born to mothers on chronic anticonvulsant therapy, only one showed PIVKA-II. Eight breast-fed infants who were given neonatal vit K did not develop a deficiency by two months of age. A K deficient infant given 1 mg vit K and then fed entirely by parenteral nutrition without supplemental vit K showed absence of PIVKA-II for five weeks. In summary, 2.6% of all newborns may be vit K deficient at birth. While most K deficient infants were born of normal pregnancies and deliveries, SGA infants were more likely to be PIVKA positive. Vit K is stored in newborns to an appreciable degree. |
| Databáze: | OpenAIRE |
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