Anti-Müllerian hormone substance from follicular fluid is positively associated with success in oocyte fertilization during in vitro fertilization
| Autor: | Chie Takahashi, Rie Sugiyama, Hiroe Ito, Keiichi Isaka, Masahiro Kazuka, Atsuya Fujito |
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| Rok vydání: | 2008 |
| Předmět: |
endocrine system
medicine.medical_specialty Pregnancy In vitro fertilisation endocrine system diseases biology urogenital system medicine.medical_treatment Obstetrics and Gynecology Anti-Müllerian hormone medicine.disease Oocyte Follicular fluid female genital diseases and pregnancy complications Andrology Follicle Human fertilization Endocrinology medicine.anatomical_structure Reproductive Medicine Internal medicine biology.protein medicine hormones hormone substitutes and hormone antagonists Fertilisation |
| Zdroj: | Fertility and Sterility. 89:586-591 |
| ISSN: | 0015-0282 |
| Popis: | Objective To determine whether the anti-Mullerian hormone (AMH) level in follicular fluid is associated with success in oocyte fertilization during in vitro fertilization (IVF) cycles. Design Retrospective study. Setting Tokyo Medical University hospital. Patient(s) Thirty-one women undergoing IVF cycles. Intervention(s) The women were divided into two groups according to the success or failure of fertilization. Follicular fluid samples were obtained from a single follicle in each patient. Main Outcome Measure(s) Assessment of values for AMH, inhibin B, and estradiol from follicular fluid and serum on the day of oocyte retrieval during IVF treatment. Result(s) The follicular fluid AMH levels from fertilized patients (group 1) were 3.42 times higher than from nonfertilized (group 2). There was no correlation between the ratio of the high quality grade embryos and either serum AMH or inhibin B levels. There was no statistically significant correlation between serum AMH and the number of oocytes. However, there was a strong correlation between levels of serum estradiol, inhibin B, and the number of oocytes. Conclusion(s) Oocytes are more likely to be fertilized when follicles are able to make high concentrations of AMH in the follicular fluid. Thus, AMH could be a prediction marker for fertilization. |
| Databáze: | OpenAIRE |
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