Effect of third molar absence on development of masticatory muscles in EL mice
| Autor: | Itaru Tashima, Yuki Kota, Megumi Nariyama, Yoshinobu Asada, Tadafumi Tomohiro, Akira Yamane |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Molar
medicine.medical_specialty Chemistry Mandible Synaptogenesis Anatomy medicine.disease Neuromuscular junction Masticatory force Hypodontia Nicotinic acetylcholine receptor Endocrinology medicine.anatomical_structure stomatognathic system Maxilla Internal medicine Pediatrics Perinatology and Child Health medicine Dentistry (miscellaneous) |
| Zdroj: | Pediatric Dental Journal. 20:122-129 |
| ISSN: | 0917-2394 |
| DOI: | 10.1016/s0917-2394(10)70204-4 |
| Popis: | We investigated the effect of the lack of the third molar on synaptogenesis at the neuromuscular junction of masticatory muscles in EL/ Sea (Sea) mice, in which tooth bud of all third molars disappears in the process of development. We analyzed the mRNA expression levels of the nicotinic acetylcholine receptor (nAChR) α , e, and γ subunits at 3, 6, and 12 weeks of age in the masseter and temporalis muscles of Sea mice, and in the control strain EL/Kwl (Kwl) mice, using real-time PCR. In the Sea, no third molars erupted over the oral mucous membrane during the experimental period. In the Kwl, at 3 weeks of age, no third molars had erupted over the oral mucous membrane, but they partially had emerged over the maxilla and mandible and, after 3 weeks of age, completely erupted over the oral mucous membrane. In the masseter, the expression levels of the α , e, and γ subunit mRNAs in the Sea mice were 92% ( P P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect