Streptonigrin biosynthesis. 4. Details of the tryptophan metabolism

Autor:	Dennis S. Darling, Steven J. Gould, Michael E. Squillacote, Chiu Chin Chang, John D. Roberts
Rok vydání:	1980
Předmět:	Stereochemistry Quinoline Tryptophan General Chemistry Metabolism Tryptophan Metabolism Biochemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry Streptonigrin chemistry Heteronuclear molecule Biosynthesis Bond cleavage
Zdroj:	Journal of the American Chemical Society. 102:1707-1712
ISSN:	1520-5126 0002-7863
DOI:	10.1021/ja00525a040
Popis:	Details of the metabolism of tryptophan leading to the biosynthesis of streptonigrin have been elucidated. These include identification of L-tryptophan as the natural precursor, the isolation of an early intermediate in the pathway, and the use of ^(15)N-^(13)C heteronuclear spin couplings to eludicate the N-C bond cleavage leading to the 4-phenylpicolinic acid portion (C-D rings). Additional feedings have apparently eliminated the possible involvement of all known pathways leading to quinoline rings; suggestions for the origin of this portion (A-B rings) are presented.
Databáze:	OpenAIRE
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