Anti-osteoclastogenic action of active vitamin D
| Autor: | Hisashi Takasu |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Medicine (miscellaneous) chemistry.chemical_element Calcium Biology In vitro Bone resorption medicine.anatomical_structure Endocrinology chemistry Osteoclast In vivo Internal medicine Precursor cell medicine Vitamin D and neurology Immediate early gene |
| Zdroj: | Nutrition Reviews. 66:S113-S115 |
| ISSN: | 0029-6643 |
| DOI: | 10.1111/j.1753-4887.2008.00098.x |
| Popis: | Active vitamin D and its analogs, which have been recognized to potentiate both bone resorption and formation, increase bone volume by inhibiting accelerated bone resorption at pharmacological doses. This mechanism is, at least in part, independent of intestinal and renal calcium regulating activities. The study described here found that active vitamin D directly acts upon osteoclast precursor cells and suppresses their differentiation in vitro. Screening vitamin D analogs for this activity led to a new candidate of bone effective drug, suggesting the importance of this activity even in vivo. These findings provide new insight into understanding the effect of vitamin D on bone and the possibility of using active vitamin D as a therapeutic agent. |
| Databáze: | OpenAIRE |
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