Analysis and follow-up of type 1 choroidal neovascularisation with optical coherence tomography–angiography after antiangiogenic treatment
| Autor: | Raúl Torrecillas-Picazo, N. Ruiz del Río, R. Ramón-Cosín, Antonio Duch-Samper, J.M. Hervás Hernandis, I. Almor Palacios, M. Cerdà-Ibáñez |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Treatment response genetic structures business.industry General Medicine Optical coherence tomography angiography Macular degeneration medicine.disease 01 natural sciences eye diseases Surgery 010309 optics 03 medical and health sciences 0302 clinical medicine Ophthalmology 0103 physical sciences 030221 ophthalmology & optometry medicine Standard protocol sense organs business After treatment Medical systems |
| Zdroj: | Archivos de la Sociedad Española de Oftalmología (English Edition). 92:265-272 |
| ISSN: | 2173-5794 |
| DOI: | 10.1016/j.oftale.2017.02.010 |
| Popis: | Aim To describe the characteristics of type 1 choroidal neovascularisation (CNV) in age-related macular degeneration (ARMD) using two different optical coherence tomography angiography (OCT-A) devices sequentially during a standard protocol of three intravitreal injections of an anti-vascular endothelial growth factor (anti-VEGF). Methods The study included 6 eyes with naive neovascular ARMD. Macular OCT-A images were acquired using AngioPlex Cirrus HD-OCT 5000 (Carl Zeiss Meditec, Inc., Dublin, USA) and DRI OCT Triton SS-OCT Angio (Topcon, Medical Systems, Inc., Oakland, NJ, USA). The macular OCT-A scan covered an area of 3 mm × 3 mm. Distinct morphological patterns and quantifiable features of the neovascular membranes were studied on en face projection images, which were taken at different stages of the follow-up. Results Treatment response could be estimated using the OCT-A criteria of CNV activity. Higher activity scores before treatment resulted in a greater decrease in the membrane area. The estimated net decline in area ranged from 83.5% to 1.4%. The OCT-A performed one-week after treatment revealed the greatest area reductions. Conclusions OCT-A provides new possibilities for the non-invasive assessment of features of neovascular networks and CNV structural morphology. Newly described activity criteria can also guide therapeutic decisions, and help in evaluating responses. Quantitative and qualitative information can be provided with this technique. However, further software development and future investigation are essential to define the role of this tool on a daily basis. |
| Databáze: | OpenAIRE |
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