Elevated serum parathormone levels are associated with myocardial iron overload in patients with β-thalassaemia major
| Autor: | Ioanna Tsatra, George Katzos, Miranda Athanassiou-Metaxa, Athanasios Christoforidis, Marina Economou, Meropi Dimitriadou, Liana Fidani, Efthimia Vlachaki |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Cardiomyopathy Myocardial iron Magnetic resonance imaging Hematology General Medicine β thalassaemia medicine.disease Elevated serum Endocrinology Internal medicine medicine Vitamin D and neurology In patient business Cause of death |
| Zdroj: | European Journal of Haematology. 84:64-71 |
| ISSN: | 1600-0609 0902-4441 |
| DOI: | 10.1111/j.1600-0609.2009.01349.x |
| Popis: | Objectives Despite advances in conventional treatment, iron-induced cardiomyopathy is still the most frequent cause of death among patients with beta-thalassaemia major. Recent studies have correlated increased myocardial iron content to decreased levels of vitamin D in thalassaemic patients. The aim of this study was to measure parathormone (PTH) and metabolites of vitamin D and consequently to investigate whether these parameters predispose to myocardial iron overload in patients with beta-thalassaemia major. Methods In 62 patients (29 M and 33 F, mean age: 22.79 +/- 6.18 yr) with beta-thalassaemia major levels of intact parathormone (iPTH) and vitamin D metabolites [25(OmicronH)D(3) and 1,25(OmicronH)(2)D(3)] were measured in serum. Additionally, estimation of myocardial iron content was performed by magnetic resonance imaging, whereas mean serum ferritin concentrations were calculated for 1 yr prior to the study. Results Results showed markedly decreased levels of serum 25(OH)D(3) in 37 patients (60%), whereas 7 patients (11%) had borderline 25(OH)D(3) levels (between 50 and 75 nmol/L). Serum iPTH levels were significantly higher in patients having increased myocardial iron compared to those having normal myocardial iron (44.04 +/- 22.09 pg/mL vs. 31.39 +/- 14.30 pg/mL, P = 0.017). Multivariant regression analysis identified PTH levels as the major predictor of increased myocardial iron. |
| Databáze: | OpenAIRE |
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