Immunoblotting reactivity of sera from patients with autoimmune connective tissue diseases against Epstein-Barr nuclear antigen (EBNA) polypeptides
| Autor: | M. Segondy, J. Ngou |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Microbiology (medical)
Autoimmune disease biology Immunology Connective tissue medicine.disease_cause medicine.disease Epstein–Barr virus Virology Connective tissue disease Pathogenesis Immune system medicine.anatomical_structure Antigen immune system diseases hemic and lymphatic diseases medicine biology.protein Antibody |
| Zdroj: | Serodiagnosis and Immunotherapy in Infectious Disease. 8:105-108 |
| ISSN: | 0888-0786 |
| DOI: | 10.1016/s0888-0786(96)80008-4 |
| Popis: | The antibody responses to Epstein-Barr nuclear antigen (EBNA) polypeptides were analyzed by immunoblotting in 93 patients with autoimmune connective tissue diseases (ACTD) in comparison with 50 clinically healthy control subjects. Antibody frequencies to EBNA-2, -4 and -6 were signficantly higher in patients than in controls. Among the patients with ACTD, those with systemic lupus erythematosus (SLE) showed a significant increase in the frequency of anti-EBNA-3 antibodies. These results confirm the particularity of the antibody responses against Epstein-Barr virus (EBV) polypeptides in patients with ACTD; they could either reflect basic immune disturbances or suggest a participation of EBV in the pathogenesis of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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