| Autor: |
Yong Joon Lee, Jee Ye Kim, Seung Hyuck Jeon, Heejin Nam, Jae Hyung Jung, Minwoo Jeon, Eui-Soon Kim, Soong June Bae, Juneyoung Ahn, Tae-Kyung Yoo, Woo Young Sun, Sung Gwe Ahn, Joon Jeong, Su-Hyung Park, Woo Chan Park, Seung Il Kim, Eui-Cheol Shin |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Science Immunology. 7 |
| ISSN: |
2470-9468 |
| DOI: |
10.1126/sciimmunol.abn8390 |
| Popis: |
Despite being a standard treatment option in breast cancer, immune checkpoint inhibitors (ICIs) are only efficacious for a subset of patients. To gain a better understanding of the antitumor immune response in breast cancer, we examined the heterogeneity of CD8 + T cells in tumors, metastatic lymph nodes (mLNs), and peripheral blood from patients with early breast cancer ( n = 131). Among tissue-resident memory CD8 + T (T RM ) cells, including virus- and tumor-specific CD8 + T cells, CD39 expression was observed in a tumor-specific and exhausted subpopulation in both tumors and mLNs. CD39 + T RM cells from tumors and mLNs exhibited a phenotypic similarity and clonally overlapped with each other. Moreover, tumor or mLN CD39 + T RM cells clonally overlapped with CD39 − T RM and non-T RM cells in the same compartment, implying a tissue-specific differentiation process. These inter-subpopulationally overlapping CD39 + T RM clonotypes were frequently detected among effector memory CD8 + T cells in peripheral blood, suggesting a systemic clonal overlap. CD39 + T RM cell enrichment was heterogeneous among molecular subtypes of breast cancer, which is associated with the different role of antitumor immune responses in each subtype. In vitro blockade of PD-1 and/or CTLA-4 effectively restored proliferation of CD39 + T RM cells and enhanced cytokine production by CD8 + T cells from tumors or mLNs, particularly in the presence of CD39 + T RM enrichment. This suggests that CD39 + T RM cells have a capacity for functional restoration upon ICI treatment. Thus, our study indicates that CD39 + T RM cells with a clonal overlap across compartments are key players in antitumor immunity in breast cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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