Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell
| Autor: | Sik Lok Lam, Hung Kay Lee, Liqi Wan, Pei Guo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Molecular switch
Chemistry education fungi Metals and Alloys Rational design food and beverages General Chemistry Combinatorial chemistry Catalysis Dissociation (chemistry) Surfaces Coatings and Films Electronic Optical and Magnetic Materials Metal chemistry.chemical_compound visual_art Materials Chemistry Ceramics and Composites visual_art.visual_art_medium A-DNA AP site Chemical stability DNA |
| Zdroj: | Chemical Communications. 56:10127-10130 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/d0cc03774e |
| Popis: | Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed. |
| Databáze: | OpenAIRE |
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