Platelet Aggregation, Malondialdehyde Generation and Production Time in Children with Sickle Cell Anaemia
| Autor: | George R. Buchanan, Christine A. Holtkamp |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Cell Population Stimulation Hematology Malondialdehyde Adenosine diphosphate chemistry.chemical_compound Endocrinology medicine.anatomical_structure Epinephrine chemistry Internal medicine medicine Platelet Platelet activation business education medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 46:690-693 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0038-1653454 |
| Popis: | SummaryIn view of prior reports of platelet activation in the sickling disorders, platelet aggregation, malondialdehyde (MDA) production following stimulation with N-ethylmaleimide, and/or production time (survival) measurements were examined in 44 children with homozygous sickle cell disease. Aggregation in response to epinephrine, collagen, and adenosine diphosphate was similar to or only slightly less than in normal black controls, rendering highly unlikely the circulation of a sizable population of refractory or “exhausted” platelets. The platelets from the normal blacks aggregated less in response to epinephrine than those from white control subjects. MDA generation in sickle cell platelets was not increased, and platelet production time was not shortened in 6 patients studied during crisis. These observations do not support the occurrence of a marked degree of platelet activation and consumption in sickle cell anaemia. |
| Databáze: | OpenAIRE |
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