m5C Goes Viral
| Autor: | Karen L. Beemon, Shelby Winans |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Messenger RNA Cell virus diseases RNA Translation (biology) Methylation Biology Group-specific antigen Microbiology Cell biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Virology RNA splicing medicine Parasitology Genomic rna 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Cell Host & Microbe. 26:154-155 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2019.07.019 |
| Popis: | In this issue of Cell Host & Microbe, Courtney et al. (2019a) find that HIV-1 genomic RNA has much more m5C than cellular mRNA. Deleting the m5C “writer” NSUN2 decreases HIV-1 m5C levels, promotes translation of the HIV-1 5′ gag gene, and alters splicing at the A2 site. |
| Databáze: | OpenAIRE |
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