| Autor: |
Sayani Chattopadhyay, Leandro B. C. Teixeira, Laura L. Kiessling, Jonathan F. McAnulty, Ronald T. Raines |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.1101/2021.09.22.461420 |
| Popis: |
Transforming growth factor-{beta} (TGF-{beta}) plays important roles in wound healing. The activity of TGF-{beta} is initiated upon binding of the growth factor to extracellular domains of its receptors. We sought to facilitate activation by clustering these extracellular domains. To do so, we used a known peptide that binds to TGF-{beta} receptors without diminishing their affinity for TGF-{beta}. We conjugated this peptide to a collagen-mimetic peptide that can anneal to damaged collagen in a wound bed. We find that the conjugate enhances collagen deposition and wound closure in mice in a manner consistent with the clustering of TGF-{beta} receptors. This strategy provides a means to upregulate the TGF-{beta} signaling pathway without adding exogenous TGF-{beta} and could inspire means to treat severe wounds. TOC Graphic O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=107 SRC="FIGDIR/small/461420v1_ufig1.gif" ALT="Figure 1"> View larger version (52K): org.highwire.dtl.DTLVardef@e5974eorg.highwire.dtl.DTLVardef@130bbc9org.highwire.dtl.DTLVardef@78c32dorg.highwire.dtl.DTLVardef@55db4b_HPS_FORMAT_FIGEXP M_FIG C_FIG |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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