A Novel Serum Marker, Total Prostate Secretory Protein of 94 Amino Acids, Improves Prostate Cancer Detection and Helps Identify High Grade Cancers at Diagnosis

Autor:	Hélène Dulude, Robert K. Nam, John Trachtenberg, Marjan Emami, Ants Toi, Jonathan R. Reeves, Steven A. Narod, Chandra J. Panchal, Luc Daigneault, Linda Sugar, Michael Jewett
Rok vydání:	2006
Předmět:	Oncology PCA3 Gynecology medicine.medical_specialty Prostate biopsy medicine.diagnostic_test business.industry Urology Case-control study Cancer medicine.disease Prostate cancer Prostate-specific antigen medicine.anatomical_structure Prostate Internal medicine medicine MSMB business
Zdroj:	Journal of Urology. 175:1291-1297
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(05)00695-6
Popis:	Purpose: New biomarkers for prostate cancer are needed. We determined whether a novel serum marker, total PSP94 can be used to accomplish these goals.Materials and Methods: We conducted a case-control study of 1,212 men with no previous history of prostate cancer and who underwent a prostate biopsy from 1998 to 2000 because of an increased PSA or an abnormal DRE. Serum PSP94 levels were assessed using a sandwich enzyme-linked immunosorbent assay technique. Cases were patients with prostate cancer, and controls were patients who had no evidence of cancer. Multivariate logistic regression analysis was used to determine whether or not PSP94 levels improved the predictive value for prostate cancer.Results: Of the 1,212 men 596 (49.2%) had cancer detected. The median PSP94 level was significantly lower among cases (2.60 ng/ml) than among controls (3.40 ng/ml, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e3e669eeaaa0d4a404828e502e127970 https://doi.org/10.1016/s0022-5347(05)00695-6 Zobrazit plný text záznamu