ChemInform Abstract: FORMAL SYNTHESIS OF LAVENDAMYCIN METHYL ESTER: THE REGIOSELECTIVE SYNTHESIS TO THE BROMOQUINOLINEQUINONE SYSTEMS OF KEY INTERMEDIATE

Autor:	Takashi Ishizu, Satoshi Hibino, Masataka Ichikawa, Miko Okazaki, K. Sato
Rok vydání:	1985
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Formal synthesis Pictet–Spengler reaction chemistry Bicyclic molecule Stereochemistry Regioselectivity General Medicine Lavendamycin Aldehyde
Zdroj:	Chemischer Informationsdienst. 16
ISSN:	0009-2975
DOI:	10.1002/chin.198527227
Popis:	Synthese de l'[hydroxy-8 quinolyl-2]-1 methyl-4 β-carbolinecarboxylate-3 d'ethyle (A) par reaction de Pictet Spengler de benzyloxy-8 quinoleinecarbaldehyde-2 et de β-methyl tryptophanate d'ethyle suivie d'hydrogenolyse; a partir de A par l'intermediaire de bromation puis d'oxydation, obtention des esters d'ethyle et de methyle de l'acide [bromo-7 dihydro-5,8 dioxo-5,8 quinolyl-2]-1 methyl-4 β-carbolinecarboxylique-3; l'ester de methyle a deja ete transforme en ester de methyle de lavendamycine
Databáze:	OpenAIRE
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