Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U-13C]linoleic acid
| Autor: | Hideyuki Sasaki, Terue Kawabata, Tomohiro Rogi, Mika Ito, Hisanori Tokuda, Toshiaki Sueyasu, Hiroshi Kawashima, Sayaka Horiguchi, Hiroshi Shibata, Yoshihisa Kaneda |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty 030109 nutrition & dietetics FADS1 Linoleic acid Clinical Biochemistry Area under the curve Human trial 030209 endocrinology & metabolism Cell Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology chemistry Biosynthesis Internal medicine medicine Allele Long chain Polyunsaturated fatty acid |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 148:1-8 |
| ISSN: | 0952-3278 |
| DOI: | 10.1016/j.plefa.2019.07.003 |
| Popis: | Long-chain polyunsaturated fatty acids (LCPUFAs) are important constituents of biomembranes. Observation of blood fatty acids indicated that LCPUFA biosynthesis is affected by aging and FADS polymorphisms. This study examined the effects of aging and FADS polymorphisms on LCPUFA biosynthetic capacity via direct quantification using [U-13C]linoleic acid. Healthy young (25–34 years) and elderly (65–74 years) participants were administered [U-13C]linoleate, and its metabolites were monitored for 14 days. The time of maximum plasma concentration of 13C-arachidonic acid (ARA) was 4–5 days. The area under the curve of the 13C-ARA concentration differed by FADS1 rs174547 polymorphism (TT [100%] > TC [57%] > CC [37%]). Among C allele carriers, 13C-ARA formation was 32% lower in elderly than in young participants. This is the first report to directly demonstrate that LCPUFA biosynthetic capacity is regulated by FADS1 polymorphisms and decreased by aging in FADS1 C allele carriers. |
| Databáze: | OpenAIRE |
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