Anti-musk Myasthenic Crisis in the Puerperium: The Management Dilemma
| Autor: | Peter Appiah–Thompson, Benedicta Thompson, Olukemi Olawaiye Dampson, Paul Masiowski, Yaw Asante Awuku |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pediatrics
medicine.medical_specialty Environmental Engineering business.industry medicine.medical_treatment Autoantibody medicine.disease Industrial and Manufacturing Engineering Neuromuscular junction Myasthenia gravis Surgery Dilemma medicine.anatomical_structure Pharmacotherapy Prednisone Postsynaptic potential Percutaneous endoscopic gastrostomy medicine business medicine.drug |
| Zdroj: | British Journal of Medicine and Medical Research. 10:1-5 |
| ISSN: | 2231-0614 |
| Popis: | Myasthenia gravis (MG) is a chronic neuromuscular junction (NMJ) dysfunction with a wide spectrum of neurological manifestations. MG is as a result of autoantibodies directed against NMJ at the postsynaptic level involving nicotinic or other postsynaptic antigens. The newly identified subtype of MG with antibodies against the muscle-specific receptor tyrosine kinase (Anti-MuSK) shows an unpredictable response to current MG treatment. The initial presentation of this disease entity often poses a diagnostic challenge and a treatment dilemma to the clinician. We present a case of life threatening Anti-MuSK-positive myasthenic crisis occurring during puerperium which required a temporary surgical airway and percutaneous endoscopic gastrostomy tube for feeding. She had dysphonia for 7 years but was not diagnosed. The complications and management dilemma of this case report are highlighted. Case Study Thompson et al.; BJMMR, 10(7): 1-5, 2015; Article no.BJMMR.20381 2 |
| Databáze: | OpenAIRE |
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