Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
| Autor: | Muhammad Imran, Ali Imran, Abdur Rauf, Muhammad Atif, Farhan Saeed, Muhammad Umair Arshad, Sami Bawazeer, Dennis G. Peters, Bashir Ahmad, Zafar Ali Shah, Mohammad S. Mubarak |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
0303 health sciences biology business.industry 030302 biochemistry & molecular biology Cancer biology.organism_classification medicine.disease_cause medicine.disease HeLa 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis medicine Viability assay Signal transduction Kaempferol business Protein kinase B PI3K/AKT/mTOR pathway Oxidative stress |
| Zdroj: | Phytotherapy Research. 33:263-275 |
| ISSN: | 0951-418X |
| Popis: | Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti-inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B) and human T-cell leukemia/lymphoma virus-I (HTLV-I) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2). Accordingly, the aim of the present review is to collect information pertaining to the effective role of kaempferol against various degenerative disorders, summarize the antioxidant, anti-inflammatory, anticancer, antidiabetic, and antiaging effects of kaempferol and to review the progress of recent research and available data on kaempferol as a protective and chemotherapeutic agent against several ailments. |
| Databáze: | OpenAIRE |
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