Actin-Interacting Proteins in flagellated pathogenic Leishmania spp.: a genome-based bioinformatics report on profilins, formins and katanins

Autor:	R. Araujo-Filho, Ana Carolina Landim Pacheco, Marcília P. Costa, Diana Oliveira, Elton J R Vasconcelos, J. J. S. Gouveia, Michely C. Diniz, Michel T. Kamimura, Fabiana F. Araújo
Rok vydání:	2008
Předmět:	Genetics Sequence analysis In silico Katanin macromolecular substances Biology Flagellum Bioinformatics Genome Profilin Formins biology.protein Neurology (clinical) Gene
Zdroj:	International Journal of Functional Informatics and Personalised Medicine. 1:234
ISSN:	1756-2112 1756-2104
DOI:	10.1504/ijfipm.2008.021389
Popis:	In search for genomic and proteomic evidences of flagellar genes/proteins in Leishmania spp., we have used available databases and bioinformatics tools to distinguish Actin-Interacting Proteins (AIPs) that are flagellar and, also, probable virulence factors. Here we present results of sequence and structural analyses of profilins, formins and katanins, whose sequences were in silico selected for predicting viable roles on flagellum assembly, disassembly and dynamics in terms of intraflagellar mechanisms. Taken together, our results provide the first bioinformatics analyses of Leishmania profilin, katanin and formin genes and their gene products to contribute to a more detailed annotation of these important AIPs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e3d90774ebd9f78e67fa3e14471f4a6b https://doi.org/10.1504/ijfipm.2008.021389 Zobrazit plný text záznamu