Neurotrophin-3 (NT-3) diminishes susceptibility of the oligodendroglial lineage to AMPA glutamate receptor-mediated excitotoxicity
| Autor: | Aki Itoh, Bryan Kavanaugh, Judith B. Grinspan, Jacqueline S. Beesley, Takayuki Itoh, David E Pleasure |
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| Rok vydání: | 2000 |
| Předmět: |
animal structures
fungi Excitotoxicity Glutamate receptor Neurotrophin-3 AMPA receptor Tropomyosin receptor kinase A Biology medicine.disease_cause Tropomyosin receptor kinase C Cell biology Cellular and Molecular Neuroscience nervous system Immunology medicine biology.protein Low-affinity nerve growth factor receptor Neurotrophin |
| Zdroj: | Journal of Neuroscience Research. 60:725-732 |
| ISSN: | 1097-4547 0360-4012 |
| DOI: | 10.1002/1097-4547(20000615)60:6<725::aid-jnr4>3.0.co;2-v |
| Popis: | Prior reports demonstrated that cells of the oligodendroglial lineage are susceptible to excitotoxic necrosis mediated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluR), and also showed that these cells express the high affinity neurotrophin receptors, TrkC and TrkA. We now report that: a) oligodendroglial progenitors (OP) and immature oligodendroglia are more vulnerable to AMPA-GluR-mediated excitotoxicity than are mature oligodendroglia; b) TrkC expression falls substantially during differentiation of cultured OP to mature oligodendroglia, whereas TrkA expression increases markedly; and c) neurotrophin-3, and to a lesser extent, nerve growth factor, protect the oligodendroglial lineage against AMPA-GluR-mediated excitotoxicity. |
| Databáze: | OpenAIRE |
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