Persistence and clinical relevance of Zika virus in the male genital tract
| Autor: | Edilson Damke, Jorge Juarez Vieira Teixeira, Marcia Edilaine Lopes Consolaro, Analine R B de A Carvalho, Fábio A. Kurscheidt, Cristiane S S Mesquita, Tamy T Suehiro, Raquel P. Souza, Gabrielle Marconi Zago Ferreira Damke, Vânia Ramos Sela da Silva |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
biology business.industry Urology Physiology Prostatitis Semen medicine.disease biology.organism_classification Virus Zika virus 03 medical and health sciences Flavivirus 030104 developmental biology 0302 clinical medicine Haematospermia Oligospermia 030220 oncology & carcinogenesis medicine Clinical significance medicine.symptom business |
| Zdroj: | Nature Reviews Urology. 16:211-230 |
| ISSN: | 1759-4820 1759-4812 |
| DOI: | 10.1038/s41585-019-0149-7 |
| Popis: | Zika virus (ZIKV) is a re-emerging mosquito-transmitted flavivirus associated with congenital abnormalities in newborns and with Guillain-Barre syndrome in adults. The virus can also be sexually transmitted and can persist in the male genital tract. Studies evaluating the kinetics of ZIKV in seminal shedding of men who have been infected, as well as in animal and cellular models of infection, have shown that, in addition to the testis and epididymis, the prostate and seminal vesicles could also be involved in persistent ZIKV infection. Additionally, some studies have reported that men infected with ZIKV can present with genitourinary symptoms such as haematospermia, prostatitis, painful ejaculation, penile discharge, and oligospermia; however, little is known about the effect of ZIKV on fertility. Understanding the mechanisms that underlie persistent ZIKV infections in men is crucial to developing guidelines, effective vaccines, and therapies. |
| Databáze: | OpenAIRE |
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