| Popis: |
A case of diffuse well differentiated lymphocytic lymphoma with associated leukopenia, is described. The colony-forming unit (CFU-C) assay was used to quantitate myeloid precursor cells and to test for the presence of suppressor cells and/or serum factors inhibiting myeloid cell proliferation. Mild suppression of CFU-C was noted with the patient's bone marrow cells in coculture studies with normal marrow. The patient's serum, when added to the culture of normal bone marrow cells, produced a marked decrease in CFU-C. Treatment with combination chemotherapy (prednisone, cyclophosphamide, and vincristine) produced a clinical response with correction of the leukopenia. Post-treatment serum did not produce a significant reduction in CFU-C from normal bone marrow. |
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