| Autor: |
Ecem Baltan, Erdinç Serin, Burak Yasin Avci, Işil Kibar Akilli, Ayşe Sürhan Çinar |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Turkish Journal of Biochemistry. 47:672-679 |
| ISSN: |
1303-829X |
| DOI: |
10.1515/tjb-2022-0044 |
| Popis: |
Objectives Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system. In our study; we aimed to evaluate serum PAI-1 and other biochemical parameters of COVID-19 patients in terms of disease course and mortality. Methods A total of 40 COVID-19 patients were hospitalized in the service and intensive care unit (ICU) of our hospital from October to December 2020 and 20 healthy volunteers were included in our study. The patients were grouped as those who transferred to the ICU from the service and transferred to service from the ICU. The first and second values of the same patients in both the service and the ICU were analyzed by SPSS. Results The PAI-1 levels of the patients in the ICU were significantly higher than the levels of the same patients in the service and the healthy control group (p Conclusions In our study, we found that PAI-1 levels increased significantly with the increase in mortality in COVID-19 patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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