A cell-laden nanofiber/hydrogel composite structure with tough-soft mechanical property

Autor:	Jinah Jang, Jongwan Lee, Dong-Woo Cho, Tae-Ha Song, Hana Oh, Young Hun Jeong
Rok vydání:	2013
Předmět:	Nanocomposite Materials science Physics and Astronomy (miscellaneous) Biocompatibility Composite number technology industry and agriculture Connective tissue Electrospinning medicine.anatomical_structure Tissue engineering Nanofiber Self-healing hydrogels medicine Composite material
Zdroj:	Applied Physics Letters. 102:211914
ISSN:	1077-3118 0003-6951
DOI:	10.1063/1.4808082
Popis:	Connective tissue is a factor of great importance in tissue engineering and regenerative medicine because it has a limited life but complicated mechanical properties. In this study, we present a reinforcement method of hydrogel using patterned nanofibers to mimic native connective tissues with selective engagement of load carrying constituents. We incorporated a three-dimensional nanofibrous frame fabricated using direct-write electrospinning with a hydrogel matrix. Three types of nanofiber-reinforced hydrogel composite were fabricated and their dual aspects of mechanical properties for compressive load were identified. It was demonstrated that the constructed composite had sufficient biocompatibility as well as connective tissue-like mechanical properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e3b28d7f1b8433c97a832e5e02775ee0 https://doi.org/10.1063/1.4808082 Zobrazit plný text záznamu