Alergia e intolerancia a antiinflamatorios no esteroideos en pediatría Comité Nacional de Alergia
| Autor: | Cesar Martin Bozzola, María Paula Sarraquigne, Andrea Irene Mariño, Juan Manuel Suárez García |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
Allergy Innate immune system biology business.industry medicine.drug_class media_common.quotation_subject Provocation test Antibiotics medicine.disease Hypersensitivity reaction 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Pediatrics Perinatology and Child Health Immunology biology.protein Medicine Cyclooxygenase Antibody business media_common |
| Zdroj: | Archivos Argentinos de Pediatria. 118 |
| ISSN: | 0325-0075 |
| DOI: | 10.5546/aap.2020.s1 |
| Popis: | Nonsteroidal anti-inflammatory drugs are widely prescribed in children. They are the second cause of drug's reactions in pediatrics after beta-lactam antibiotics, however only a part of them are hypersensitivity reactions. The prevalence of these reactions to nonsteroidal anti-inflammatory drugs in children is 0.3 %, increasing to 5 % in asthmatics. The different physiopathological mechanisms involved (inhibition of cyclooxygenase, immunoglobulin E-mediated hypersensitivity, reactive T lymphocytes and/or disturbance of innate immunity) will cause different clinical entities with diverse symptoms. The confusion between the common symptoms of a viral infection and a hypersensitivity reaction, and the variability of the clinical presentations make diagnosis a real challenge. A detailed clinical history, laboratory, skin and controlled provocation tests will provide strategies for each patient, without labeling a child who is not an allergic one, or taking unnecessary risks with those who are sensitized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|