Structures and biological activity of cinnamoyl derivatives of coumarins and dehydroacetic acid and their boron difluoride complexes

Autor:	I. V. Voevodina, Valerii F. Traven, Yan A. Ivanenkov, K. V. Tambov, Nouri Neamati, A. V. Manaev
Rok vydání:	2012
Předmět:	Quantitative structure–activity relationship biology Chemistry Stereochemistry Biological activity General Chemistry Dehydroacetic acid Coumarin In vitro Integrase chemistry.chemical_compound biology.protein Boron difluoride Cytotoxicity
Zdroj:	Russian Chemical Bulletin. 61:78-90
ISSN:	1573-9171 1066-5285
Popis:	Computer-assisted screening for Kohonen self-organizing maps in terms of the quantitative structure—activity relationship (QSAR) model revealed the high potential activity of cinnamoyl derivatives of coumarin and dehydroacetic acid and their boron difluoride complexes against a number of biological targets, including HIV-1 integrase. The pronounced inhibitory properties of dehydroacetic acid derivatives and their boron difluoride complexes against HIV-1 integrase were experimentally confirmed by in vitro testing of their antiviral activity with respect to HIV-infected cells. The data obtained suggests a correlation between the structure of the compounds studied and their biological activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e3b028ffc1c7133e7d5ce27bd78afff5 https://doi.org/10.1007/s11172-012-0012-y Zobrazit plný text záznamu Full text from SpringerLink