Tyrosine and tryptophan analogues as MAO-inhibiting prodrugs

Autor:	Jean-Noel Collard, Philippe Bey, Albert Sjoerdsma, Michael G. Palfreymana, Monique Zreika, Joseph Wagner, Ian A. McDonald
Rok vydání:	1990
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry In vivo Stereochemistry Monoamine oxidase Tryptophan Substrate (chemistry) Tyramine Tyrosine Prodrug Amino acid
Zdroj:	Amino Acids ISBN: 9789072199041
DOI:	10.1007/978-94-011-2262-7_43
Popis:	(E)-s-Fluoromethylene-m-tyrosine (FMMT) and (E)-s-fluoromethylene-5-hydroxytryptophan (FM-5-HTP) are substrates of aromatic L-amino acid decarboxylase and yield the corresponding substituted tyramine and 5-hydroxytryptamine analogues which potently and irreversibly inhibit monoamine oxidase. In addition, the tyrosine analogue is a substrate for the neutral large amino acid transport system and is thereby concentrated in cerebral tissue. In vivo, FMMT is a potent inhibitor of MAO and this effect occurs predominantly in the brain. Such selectivity offers considerable therapeutic advantages.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e3a5847c5f9262fcdc6982b2253be06c https://doi.org/10.1007/978-94-011-2262-7_43 Zobrazit plný text záznamu