Exploring Relevant Time Windows in the Association Between PM2.5 Exposure and Amyotrophic Lateral Sclerosis: A Case-Control Study in Denmark
| Autor: | Yanelli Nunez, Arin Balalian, Robbie M Parks, Mike Z He, Johnni Hansen, Ole Raaschou-Nielsen, Matthias Ketzel, Jibran Khan, Jørge Brandt, Roel Vermeulen, Susan Peters, Marc G Weisskopf, Diane B Re, Jeff Goldsmith, Marianthi-Anna Kioumourtzoglou |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | American Journal of Epidemiology. |
| ISSN: | 1476-6256 0002-9262 |
| Popis: | Studies suggest a link between PM2.5 and amyotrophic lateral sclerosis (ALS), but critical exposure windows have not been examined. We performed a case-control study on the Danish population spanning 1989 to 2013. Cases selected from the Danish National Patient Registry based on ICD codes. Five controls were randomly selected from the Danish Civil Registry and matched to a case on vital status, age, and sex. PM2.5 concentration was assigned at residential addresses using monthly predictions from a dispersion model. We used conditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), adjusting for confounding. We evaluated exposure to averaged PM2.5 concentrations 12-24 months, 2-6, and 2-11 years pre-ALS diagnosis; annual lagged exposures up to 11 years pre-diagnosis; and cumulative associations in lags 1-5 and 1-10, allowing for varying association estimates by year. We identified 3983 cases and 19,915 controls. Cumulative exposure to PM2.5 in the period 2 to 6 years pre-diagnosis was associated with ALS (OR=1.06, 95% CI: 0.99–1.13). Exposures in the 2nd, 3rd, and 4th year preceding diagnosis were individually associated with higher odds of ALS (e.g., lag-1 OR=1.04, 95% CI: 1.00–1.08). Exposure to PM2.5 within six years before diagnosis may represent a critical exposure window. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|