Nuclear lesions during rat hepatocarcinogenesis

Autor:	Christian Herens, M. Jacquemart, Lucien Koulischer, H. Barbason
Rok vydání:	1995
Předmět:	Health Toxicology and Mutagenesis Mutagen Sister chromatid exchange Biology medicine.disease_cause Tissue specificity Initiation promotion Micronucleus test Genetics medicine Cancer research Sister chromatids Carcinogenesis Molecular Biology Carcinogen
Zdroj:	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 329:153-159
ISSN:	0027-5107
DOI:	10.1016/0027-5107(95)00024-d
Popis:	Cytogenetic endpoints such as sister-chromatid exchanges (SCEs), chromosomal aberrations and micronuclei (MNs) have been widely used as indicators of genetic damage. However, no systematic attempts have been made to correlate the levels of these cytogenetic endpoints with the different steps of carcinogenesis. In the present report, the induction, accumulation and persistence of SCEs and high frequency cells (HFCs) were measured in liver cells during the initiation, promotion and progression steps of rat hepatocarcinogenesis induced by diethylnitrosamine (DEN). The results indicate that lesions leading to SCEs accumulate during initiation only. When DEN administration is longer than the duration of this first step, SCE values stabilize. After stopping the carcinogenic treatment, the SCE levels decrease to control values whether or not promotion and progression occur.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e3913ac6b00ee9012d09b1117e1e196a https://doi.org/10.1016/0027-5107(95)00024-d Zobrazit plný text záznamu Full Text from ScienceDirect