The Effectiveness of Triple Fixed-Dose Combination Therapy in the Management of Uncontrolled Arterial Hypertension

Autor:	Shukhrat Masharipov, Khurshid Ataniyazov, Dilafruz Shukurova, Gulnoz Khamidullaeva, Guzal Abdullaeva, Ravshanbek Kurbanov
Rok vydání:	2020
Předmět:	General Immunology and Microbiology General Neuroscience General Biochemistry Genetics and Molecular Biology
Zdroj:	International Journal of Biomedicine. 10:334-341
ISSN:	2158-0529 2158-0510
DOI:	10.21103/article10(4)_oa1
Popis:	The aim of our study was to identify patients with uncontrolled hypertension (UCH) who were resistant to previous antihypertensive therapy (AHT) and to assess the clinical efficacy of the fixed-dose triple combination (FDTC) therapy during 6 months. Methods and Results: The study included 156 patients with UCH. The mean age of patients was 57.81±10.8 years; the average duration of AH was 8.87±5.34 years. According to the questionnaire data, all patients received dual or triple free-combination AHT, but did not reach the target blood pressure (BP) level. After the screening stage, all patients were discontinued from previous therapy and assigned to the FDTC therapy. Patients initially taking angiotensin-converting enzyme inhibitors (n=96/61.5%) were switched to single-pill triple combination (SPTC) of perindopril, indapamide and amlodipine (Per/Ind/Aml [5mg/1.25mg/5mg]). Patients initially taking angiotensin receptor blockers (n=60/38.5%) were switched to SPTC of telmisartan, hydrochlorothiazide and amlodipine (Tel/HCTZ/Aml [40mg/12.5mg/5mg]). The primary target level for SBP and DBP was
Databáze:	OpenAIRE
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