THE STUDY OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN CHILDREN WITH UROPATHY OF THE UPPER URINARY TRACTS
| Autor: | G. N. Drannik, V. F. Peterburgskiy, V. E. Driyanskaya, N. A. Kalinina, I. V. Bagdasarova, F. Z. Gayseniuk, O. V. Lavrenchuk, T. V. Poroshina, N. A. Sevastyanova |
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| Rok vydání: | 2014 |
| Zdroj: | Health and Ecology Issues. :82-87 |
| ISSN: | 2708-6011 2220-0967 |
| DOI: | 10.51523/2708-6011.2014-11-3-15 |
| Popis: | The purpose of the work is to study the role and significance of the research for pro- (TNF-α, IL-23, MCP-1) and anti-inflammatory (TGF-β) blood cytokines in blood and urine in children with uropathy of the upper urinary tracts (UUUT). Material and methods . 52 children with UUUT (1 group) and also 43 children free of UUUT with the infected urinary system (2 group) were examined. The immuno-enzymic method ELISA and the corresponding test-systems were used to study the levels of cytokines in blood and urine. Results. The analysis showed a significant increase in the levels of all the studied pro- (TNF-α, MCP-1, IL-23) and anti-inflammatory (TGF-β 1) cytokines in the blood of the patients in groups 1 and 2. The levels of TNF-α and TGF-β in urine are considered as diagnostic markers of inflammation and fibrosis, including the state after reconstructive surgery, and that of MCP-1 in blood - as acute aggravation of chronic pyelonephritis. Conclusion. The TNF-α and TGF-β levels in blood of the children with congenital uropathy can be additional diagnostic and prognostic markers and also in the dynamics of the treatment with nephroprotection. |
| Databáze: | OpenAIRE |
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