Dual protective effect of ginger and rosemary extracts against CCl4-induced hepatotoxicity in rats
| Autor: | Wessam M Abdel-Wahab, Omnia M Khamis, Ismail A. Sadek, Amina E. Essawy |
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| Rok vydání: | 2018 |
| Předmět: |
Antioxidant
Globulin Bilirubin Health Toxicology and Mutagenesis medicine.medical_treatment CCL4 Pharmacology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology 0302 clinical medicine medicine Environmental Chemistry Liver injury biology Albumin 04 agricultural and veterinary sciences General Medicine medicine.disease 040401 food science Pollution chemistry 030220 oncology & carcinogenesis biology.protein Carbon tetrachloride Oxidative stress |
| Zdroj: | Environmental Science and Pollution Research. 25:19510-19517 |
| ISSN: | 1614-7499 0944-1344 |
| DOI: | 10.1007/s11356-018-2129-5 |
| Popis: | The present study aimed to investigate the protective effect of aqueous extracts of ginger (GE) and rosemary (RE), both individually and in combination, on carbon tetrachloride (CCl4)-induced liver injury in adult male rats. CCl4 induced significant increase in liver enzymes, bilirubin, triglycerides, and total cholesterol while total protein, albumin, and globulin were significantly decreased. Also, the activity of cytochrome P450 (CYP) and oxidative stress markers were found to be elevated with a concomitant decrease in the activity of antioxidant enzymes in hepatic tissue. Supplementation with extracts of ginger or rosemary effectively relieved most of the CCl4-induced alterations when administered singly. The joint therapy of the two extracts was more effective. The histological investigation strongly confirmed the highly protective effect of the two plant extracts in the hepatocytes. These findings suggest that rosemary and ginger extracts are effective in improving both the function and structure of the hepatocytes through their potent antioxidant effect and point out to the possibility of using a combination of both as an adjunct therapy in liver diseases. |
| Databáze: | OpenAIRE |
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